Main benefits
  • Pattern identification: Traditionally used for the pattern of Liver and Kidney Yin deficiency with Liver Qi stagnation, where lack of Yin fluids leaves the Liver under‑nourished so its Qi becomes constrained and “dry, tight, and hot.”​

  • Name and core idea: [translate:一贯煎] is often translated as “Linking Decoction” or “Continuous Decoction,” referring to its function of linking Yin nourishment with smooth Liver Qi movement so that deficiency and stagnation are treated together.​

  • Main actions in TCM: The formula nourishes Liver and Kidney Yin, enriches Blood, clears mild Deficiency Heat, and gently soothes Liver Qi, especially when dryness and tension coexist (e.g. dry throat/flanks plus rib‑side distention).​

  • Key ingredients and roles: Gou Qi Zi (Lycium / goji berry): Chief herb that nourishes Liver and Kidney Yin and Blood and moistens dryness, providing the “medium” (Blood/fluids) through which Qi can move.​ Sheng Di Huang (Raw Rehmannia): Strongly nourishes Yin, cools Blood, and generates fluids, addressing red, dry tongue and Deficiency Heat.​ Sha Shen (Glehnia) and Mai Men Dong (Ophiopogon): Supplement Yin of Lung and Stomach, moisten dryness, and help generate Jin‑Ye (body fluids).​ Dang Gui (Angelica sinensis): Nourishes and mildly moves Blood, supporting Gou Qi Zi in enriching and circulating Liver Blood.​ Chuan Lian Zi (Toosendan / Melia): The guiding herb that gently disperses constrained Liver Qi and relieves hypochondriac or chest distention without damaging Yin.​

  • Typical TCM presentation: Classical and modern monographs describe patterns with rib‑side or chest pain/distention, dry throat or mouth, possible acid regurgitation, a red, dry tongue with scant coat, and a thin or wiry pulse—seen as Yin/Blood deficiency failing to nourish the Liver, leading to Qi stagnation and mild heat.​

  • Clinical niche in formula families: Compared to more “moving” Liver‑Qi formulas (like Jia Wei Xiao Yao San), Yi Guan Jian is deficiency‑dominant: it is chosen when Yin and Blood deficiency are primary and Qi stagnation is secondary, especially with dryness signs.​

  • Classical heritage: Created by Wei Zhi‑xiu in 1770 and recorded in Xu Ming Yi Lei An (Continuation of Famous Physicians’ Classified Case Records), it is now regarded as a standard Liver‑Yin tonic for chronic Liver and Liver–Stomach patterns in modern TCM practice.​


Zhenatura.com TCM: Herbal dietary supplements of Traditional Chinese Medicine origine according to European standards!

  • Strength 10:1
  • 120 tablets per bottle
  • Double or Triple the strength as regular brands
  • Less fillers and binders
  • No pharmaceuticals or dyes
  • Thorough lab testing (heavy metals, pesticides etc.)
  • Always made in controlled cGMP certified facility
  • Unbeatable value
  • European brand
TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. We advice always to use minimum 1 packing and then evaluate with your prescriber!
This product is a dietary (food) supplement, to be taken as directed by a qualified practitioner. It is not intended to treat, cure, diagnose or prevent any disease. Not to replace a varied diet. Not to be taken if nursing or if pregnant. Not to be consumed continuously for longer than 3 months.

Common uses

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Information for professionals

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Zhenatura Yi Guan Jian Extra Strong is based on the classical Yi Guan Jian, first recorded in the Qing‑dynasty text Yi Xue Xin Wu (“New Understandings in Medicine”) by Wei Zhi‑Xiu. In the context of traditional Chinese herbal literature, this specific combination of botanicals, including Rehmannia, Ophiopogon, and Lycium, was described as a method to “nourish Yin” and “soothe the Liver” within the TCM theoretical framework. These descriptions refer exclusively to traditional Chinese herbal theory and do not relate to modern anatomical structures or scientifically verified physiological effects.

1
Liver Disease and Liver Fibrosis
https://pubmed.ncbi.nlm.nih.gov/37778517/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Chronic Hepatitis B and Liver Fibrosis:

Yi Guan Jian has been widely used in the treatment of liver fibrosis, especially in chronic hepatitis B (CHB) patients. A 2019 study identified 30 active ingredients in Yi Guan Jian, with two (methylophiopogonone A and 8-geranyloxypsoralen) showing antifibrotic effects on hepatic stellate cells in vitro. The decoction targets 224 differentially expressed genes related to liver fibrosis, modulating pathways that inhibit fibrogenesis and inflammation.

Anti-fibrotic and Hepatoprotective Effects:

Comprehensive reviews confirm that Yi Guan Jian exerts anti-fibrotic, anti-inflammatory, and hepatoprotective effects. It is effective in managing chronic hepatitis, cirrhosis, and fatty liver disease, and shows promise in protecting liver cells and reducing the progression of fibrosis.


2
Cancer Research
https://pubmed.ncbi.nlm.nih.gov/21822542/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Liver Cancer (Hepatocarcinoma):

Modified Yi Guan Jian (MYGJ) has demonstrated the ability to induce anoikis (a form of programmed cell death) in human hepatocarcinoma cells (Bel-7402), inhibiting cell growth and activating caspase-dependent apoptosis pathways. This effect is associated with downregulation of p38 MAPK signaling, suggesting potential as an adjunct therapy for liver cancer.


3
Metabolic and Cognitive Disorders
https://pubmed.ncbi.nlm.nih.gov/39725366/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Type 2 Diabetes Mellitus (T2DM) with Cognitive Dysfunction:

Animal studies show that Yi Guan Jian improves glucose homeostasis, insulin sensitivity, lipid metabolism, and cognitive function in T2DM rats. It reduces neuroinflammation, regulates neurotransmitters, and remodels gut microbiota and bile acid metabolism, likely via modulation of bile acid receptors (FXR, PXR, VDR, TGR5). These findings support its potential as a complementary therapy for metabolic and neurodegenerative complications of diabetes.


4
Digestive and Systemic Disorders
https://www.healthlaborganics.com/post/yi-guan-jian

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Chronic Gastritis, Peptic Ulcers, and Gastrointestinal Pain:

Clinical and traditional use support Yi Guan Jian for chronic gastritis, gastric and duodenal ulcers, and epigastric pain, particularly when associated with liver yin deficiency and liver qi stagnation.

Other Indications:
The formula is also used for intercostal neuralgia, anemia, malnutrition, tuberculosis, and diabetes, reflecting its broad application in nourishing yin, softening the liver, and relieving pain or chronic deficiency symptoms.


For Yi Guan Jian, take 3 tablets 2 times per day. These should be taken before or after meal.

Total pieces in package: 120 tablets

Dosage: 3 tablets

Frequency: 2 times a day before or after meal


Side effects

Appetite loss

Bloating

Digestive discomfort

Nausea


Allergies

Individuals allergic to any of the herbal ingredients should avoid use. Discontinue immediately if any allergic reactions, such as rash, itching, or swelling, occur.

Apiaceae Family

Asparagus Root

Citrus Allergy


Avoid medicine interactions

Antacids (Omeprazole, Pantoprazole, Tums)

Blood Thinners and Antiplatelet Agents

Immunosuppressants


Precautions

Discontinue use if allergic reaction occurs.

Not suitable for if you suffer from digestive problems.

Consult your herbalist or physician before use if you are taking other medications or receiving other medical treatments.

Consult your herbalist or doctor before use if you have high blood pressure, or if you are children, old or very weak.

Keep out of reach of children.

Do not use when you have a fever.


Indemnification

This product is a dietary supplement, and should only be used as prescribed by a qualified acupuncturist, herbalist, phyto- or TCM therapist. This product is not intended to diagnose, treat, prevent or cure any disease. Always consult a qualified doctor or healthcare professional before using this. A healthy lifestyle is important, as is a varied, balanced diet, for which supplements are not a substitute.

TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. 1 packing adviced and then evaluate with your prescriber!

Allergies

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Original classical patents

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