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Main benefits

  • Pattern Identification: Traditionally used for the TCM pattern of Six Stagnations (Liu Yu), which involves the combined stagnation of Qi, Blood, Phlegm, Dampness, Fire (Heat), and Food. It manifests as a feeling of focal distention or fullness in the chest and abdomen, acid regurgitation, belching, indigestion, and varying degrees of mild pain.

  • Core Function: The formula is classically said to promote the movement of Qi and resolve constraints (stagnations) of all six types.

  • Qi Stagnation as the Root: Based on the TCM principle that "Qi is the commander of Blood and fluids," the formula treats Qi stagnation as the primary cause of the other five stagnations, resolving the root blockage to allow Blood, Phlegm, Dampness, Heat, and Food to naturally disperse.

  • Key Ingredients: Xiang Fu (Cyperus Rhizome) strongly promotes Qi movement and relieves constraint; Chuan Xiong (Ligusticum) invigorates Blood and moves Qi within the Blood; Cang Zhu (Atractylodes) dries Dampness and transforms Phlegm; Zhi Zi (Gardenia Fruit) clears Heat and drains Fire downwards; Shen Qu (Massa Medicata Fermentata) reduces Food stagnation and harmonizes the Stomach.

  • Emotional Component (TCM): Highly relevant for conditions where physical digestive and chest discomfort is directly triggered or aggravated by emotional constraint, chronic stress, or repressed emotions, reflecting the tight connection between emotional wellbeing and the smooth flow of Liver Qi.

  • Region of Action: Primarily acts on the Middle Jiao (Spleen and Stomach), Liver, and chest, addressing widespread constraint that disrupts digestion, fluid metabolism, and emotional balance across these regions.

  • Classical Heritage: First recorded in the Yuan-dynasty classic Dan Xi Xin Fa (Teachings of Zhu Dan Xi) by Zhu Zhenheng in 1481, it is the most famous and foundational formula for treating complex, multi-layered stagnation.


Zhenatura.com TCM: Herbal dietary supplements of Traditional Chinese Medicine origine according to European standards!

  • Strength 10:1
  • 120 tablets per bottle
  • Double or Triple the strength as regular brands
  • Less fillers and binders
  • No pharmaceuticals or dyes
  • Thorough lab testing (heavy metals, pesticides etc.)
  • Always made in controlled cGMP certified facility
  • Unbeatable value
  • European brand
TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. We advice always to use minimum 1 packing and then evaluate with your prescriber!
This product is a dietary (food) supplement, to be taken as directed by a qualified practitioner. It is not intended to treat, cure, diagnose or prevent any disease. Not to replace a varied diet. Not to be taken if nursing or if pregnant. Not to be consumed continuously for longer than 3 months.

Common uses

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Information for professionals

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Zhenatura Yue Ju Wan Extra strong is based on the classical Yue Ju Wan (“Escape Restraint Pill”), first documented in the Yuan‑dynasty medical text Dan Xi Xin Fa (“Danxi’s Master Methods”) by the eminent physician Zhu Dan‑Xi. Within traditional Chinese herbal literature, this unique combination of botanicals, including Cang Zhu (Atractylodes Rhizome), Chuan Xiong (Ligusticum Root), Xiang Fu (Cyperus Rhizome), Shen Qu (Massa Medicata Fermentata), and Zhi Zi (Gardenia Fruit), was described as a method to “resolve the Six Stagnations” (Qi, Blood, Phlegm, Fire, Dampness, and Food) and “harmonize the Middle Jiao” in accordance with the TCM theoretical framework. These descriptions belong exclusively to the traditional conceptual system of Chinese medicine and do not refer to modern anatomy, psychology, or scientifically validated physiological effects.

1
Depression and Rapid-Onset Antidepressant Action
https://onlinelibrary.wiley.com/doi/full/10.1155/2013/184367

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • Animal research (2013, PubMed/Evid Based Complement Alternat Med) first demonstrated that a single dose of Yue Ju Wan produced significant antidepressant-like effects in mice using both the Learned Helplessness (LH) and Tail Suspension Test (TST) paradigms, with effects comparable to ketamine, both being rapid and lasting compared to conventional monoaminergic antidepressants which require weeks of repeated dosing.

    • Yue Ju Wan significantly reduced escape failures and freezing time in LH paradigm (p=0.013 and p=0.039, respectively) and reduced immobility in TST dose-dependently, with effects sustained at 24 hours.

  • Mechanistic work (2015, Nature / Scientific Reports) confirmed that Yue Ju Wan, like ketamine, produces rapid antidepressant effects by reversing mTOR signalling deficits and restoring AMPA/NMDA receptor balance in the prefrontal cortex of chronically stressed mice, with desuppression of BDNF synthesis via eEF2 dephosphorylation as a key mechanism distinct from ketamine's primary mechanism. This makes Yue Ju Wan the first herbal medicine identified with ketamine-like rapid antidepressant potential.


2
Depression and Rapid-Onset Antidepressant Action
https://pmc.ncbi.nlm.nih.gov/articles/PMC4532216/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • Pilot human RCT (2015, Frontiers in Psychiatry / Dove Press, n=18): In MDD patients (HDRS-24 ≥ 20, antidepressant-naïve), participants were randomized to Yue Ju Wan (23 g/day) + fluoxetine (20 mg/day) vs placebo + fluoxetine for 7 days.​

    • At day 3, the combination group showed a modest but statistically significant improvement in HDRS-24 (p=0.039) while the placebo + fluoxetine group did not.​

    • Response rate at day 7 (Yue Ju + fluoxetine) was significantly higher than the control group by both HDRS-24 and MADRS criteria (p=0.022; 50% vs 0% MADRS response).​

    • Serum BDNF levels increased more rapidly in the Yue Ju Wan group, consistent with preclinical findings.​

    • This is the first published human clinical evidence for rapid antidepressant effects of an herbal medicine; the study is small and exploratory but provides proof-of-concept.


3
Depression and Rapid-Onset Antidepressant Action
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70341

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

A 2026 review in the British Journal of Pharmacology gives a comprehensive mechanistic overview of Yue Ju Wan's antidepressant potential, confirming that the formula regulates Qi flow and addresses the Qi stagnation underlying depression, promotes neuroplasticity, and acts via multiple pathways (mTOR/BDNF, NMDA/glutamate, AMPK) to produce both rapid and sustained antidepressant-like effects.


4
Depression and Rapid-Onset Antidepressant Action
https://pubmed.ncbi.nlm.nih.gov/28347831/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

A 2017 review in PubMed summarized the literature on Yue Ju Wan's rapid antidepressant mechanisms and discussed its potential as an adjunct to accelerate antidepressant onset, which is clinically valuable given the 2–6 week delay with standard antidepressants.


5
Functional Dyspepsia (FD) and Gastric Motility
https://pmc.ncbi.nlm.nih.gov/articles/PMC8691044/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • Reviews of TCM for functional dyspepsia describe Yue Ju Wan–based formulas as promoting gastric motility, reducing visceral sensitivity, and regulating the brain-gut axis, with effects mediated through gastrointestinal hormones (GAS, MTL, GHR) and neural peptides.

  • A 2021 network meta-analysis of CHM formulas for FD positions Qi-regulating and stagnation-resolving formulas (the category of Yue Ju Wan) as comparably effective to prokinetic agents for overall FD symptom improvement.


6
Metabolic Syndrome, Hyperlipidemia, and Non-Alcoholic Fatty Liver Disease (NAFLD)
https://pmc.ncbi.nlm.nih.gov/articles/PMC7644301/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • Clinical and experimental data show that Yue Ju Wan can reduce serum TC, TG, and LDL-C in hyperlipidemic patients and animal models, and in metabolic syndrome rats it lowers body weight, blood pressure, and fasting blood glucose by activating AMPK-α phosphorylation and improving lipid metabolism.

  • An experimental study (2020, Evid Based Complement Alternat Med) on NAFLD/hepatosteatosis models demonstrated that Yue Ju Wan improved liver function, regulated lipid metabolism, alleviated hepatic steatosis and fibrosis, and protected hepatocytes from apoptosis, identifying it as a potential therapy for metabolic-associated fatty liver disease (MAFLD).

For Yue Ju Wan, take 3 tablets 2 times per day. These should be taken before or after meal.

Total pieces in package: 120 tablets

Dosage: 3 tablets

Frequency: 2 times a day before or after meal

Do not exceed the recommended daily dose. This supplement is not a substitute for a balanced diet.


Side effects

Dryness

Gastrointestinal discomfort

Thirst


Allergies

Individuals allergic to any of the herbal ingredients should avoid use. Discontinue immediately if any allergic reactions, such as rash, itching, or swelling, occur.

Atractylodes Rhizome

Cyperus Allergy

Gardenia Allergy

Ligusticum Rhizome

Medicated Leaven


Avoid medicine interactions

Anticoagulants

Anticoagulants or Antiplatelet Drugs

Antiplatelet medications

Cholinergic and/or anticholinergic medications

NSAIDs (Ibuprofen, Aspirin, Naproxen)


Precautions

Discontinue use if allergic reaction occurs.

Do not use if pregnant or breastfeeding.

Do not use in cases of heavy menstrual bleeding or any condition involving active bleeding.

Consult your herbalist or physician before use if you are taking other medications or receiving other medical treatments.

Only to be used by children under adult supervision.

Keep out of reach of children.

Consult your herbalist or doctor before use if you have high blood pressure, or if you are children, old or very weak.

Not suitable for if you suffer from digestive problems.


Indemnification

This product is a dietary supplement, and should only be used as prescribed by a qualified acupuncturist, herbalist, phyto- or TCM therapist. This product is not intended to diagnose, treat, prevent or cure any disease. Always consult a qualified doctor or healthcare professional before using this. A healthy lifestyle is important, as is a varied, balanced diet, for which supplements are not a substitute.

TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. 1 packing adviced and then evaluate with your prescriber!

Allergies

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