Main benefits
  • Pattern Identification: Traditionally used for the TCM pattern of "Liver and Kidney Yin Deficiency with Empty Fire," characterized by a lack of cooling fluids in the lower body leading to a false uprising of heat.​

  • Foundation Formula: Based on the famous Liu Wei Di Huang Wan (Six Flavor Rehmannia Pill), the standard formula for nourishing Yin, with the addition of two bitter-cold herbs to specifically address "steaming bone" sensation and internal heat.​

  • Empty Fire Clearing: The name "Zhi Bai" refers to the addition of Anemarrhena (Zhi Mu) and Phellodendron (Huang Bai), which are traditionally valued for their ability to "drain Fire" from the Kidneys without damaging the fluids.​

  • Essence Nourishment: Features Prepared Rehmannia (Shu Di Huang) as the sovereign herb to strongly "tonify the Jing (Essence)" and marrow, supporting the deep constitutional foundation of the body.​

  • Kidney-Liver Support: Contains Cornus (Shan Zhu Yu) to bind the Essence and Chinese Yam (Shan Yao) to strengthen the Spleen, ensuring the body can hold and generate vital substances.​

  • Yin-Yang Balance: Designed to restore the balance between Water (Yin) and Fire (Yang) in the lower burner; when Water is sufficient, it naturally anchors the Fire, preventing it from flaring upward.​

  • Three Purging Herbs: Includes Alisma (Ze Xie), Moutan (Mu Dan Pi), and Poria (Fu Ling) to drain turbidity and prevent the rich, cloying nature of the tonifying herbs from causing stagnation in the system.​

  • Classical Heritage: A renowned modification from the Zheng Zhi Zhun Sheng (Standards for Diagnosis and Treatment, 1602 AD), historically used for conditions where "Deficiency Heat" disturbs the spirit or causes night sweats.​


Zhenatura.com TCM: Herbal dietary supplements of Traditional Chinese Medicine origine according to European standards!

  • Real strength 10:1 concentration
  • 120 tablets per bottle
  • Double or Triple the strength as regular brands
  • Less fillers and binders
  • No pharmaceuticals or dyes
  • Thorough lab testing (heavy metals, pesticides etc.)
  • Always made in controlled cGMP certified facility
  • Unbeatable value
  • European brand
TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. We advice always to use minimum 1 packing and then evaluate with your prescriber!
This product is a dietary (food) supplement, to be taken as directed by a qualified practitioner. It is not intended to treat, cure, diagnose or prevent any disease. Not to replace a varied diet. Not to be taken if nursing or if pregnant. Not to be consumed continuously for longer than 3 months.

Common uses

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Information for professionals

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Zhenatura Zhi Bai Di Huang Wan Extra Strong is inspired by the classical formula Liu Wei Di Huang Wan, to which the herbs Anemarrhena (Zhi Mu) and Phellodendron (Huang Bai) were historically added. In traditional Chinese herbal literature, this specific combination was described as a method to "nourish Yin" and "clear heat" within the context of TCM theory. These descriptions refer exclusively to the traditional characterization of the ingredients within the Chinese herbal paradigm.

1
Recurrent Aphthous Stomatitis (RAS)
https://pubmed.ncbi.nlm.nih.gov/37904377/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Meta-analysis (2023): A systematic review and meta-analysis included 7 randomized controlled trials with 669 participants and found that Zhi Bai Di Huang Pian (ZBDHP) combined with Western medicine (WM) was significantly more effective for RAS than WM alone.

Results showed:

  • Improved overall clinical efficacy (RR = 1.20) Reduced recurrence rate (RR = 0.24)

  • Decreased ulcer area and pain scores Shorter ulcer healing and pain disappearance times

  • Significant reductions in serum TNF-α, IL-6, and IL-10 No adverse effects reported

The authors concluded that ZBDHP is a promising adjunct for RAS, though larger and higher-quality studies are needed.


2
Menopausal Syndrome, PCOS, and Oral Ulcers
https://pmc.ncbi.nlm.nih.gov/articles/PMC7037871/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Mechanistic and Animal Studies:

Zhi Bai Di Huang Decoction (ZBDHD) has been shown to:

Ameliorate oxidative stress and pathological changes in oral mucosa in rat models of Yin deficiency and “high fire”.

Used clinically for menopausal syndrome, polycystic ovary syndrome (PCOS), and oral ulcers related to Yin deficiency The formula’s efficacy is attributed to its ability to reduce inflammation and oxidative damage.


3
Idiopathic Central Precocious Puberty (ICPP)
https://journals.sagepub.com/doi/full/10.1177/1934578X251323772

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Meta-analysis and Review (2025): Zhi Bai Di Huang formula is one of the most frequently prescribed herbal remedies for ICPP.

Studies suggest it may:

  • Reduce primary sexual traits and serum sex hormone levels Delay sexual development by downregulating hypothalamic-pituitary-gonadal axis signaling (e.g., Kiss-1/GPR54, GnRH)

  • No serious adverse effects reported

The review highlights its promise for treating ICPP, though further research is needed to confirm efficacy and clarify mechanisms


For Zhi Bai Di Huang Wan, take 3 tablets 2 times per day. These should be taken before or after meal.

Total pieces in package: 120 tablets

Dosage: 3 tablets

Frequency: 2 times a day before or after meal


Side effects

Fatigue & Weakness

Increased Urination

Mild Digestive discomfort


Allergies

Individuals allergic to any of the herbal ingredients should avoid use. Discontinue immediately if any allergic reactions, such as rash, itching, or swelling, occur.

Anemarrhena Allergy

Corn or Starch Allergy

Phellodendron Allergy

Rehmannia Root Allergy


Avoid medicine interactions

Antibiotics

Antidiabetic Drugs

Cold and Flu Medications

Diuretics

Hormonal medications

Immunosuppressants


Precautions

Discontinue use if allergic reaction occurs.

Do not use in combination with cold medicines.

Consult your herbalist or physician before use if you are taking other medications or receiving other medical treatments.

Consult your herbalist or doctor before use if you have high blood pressure, or if you are children, old or very weak.

Keep out of reach of children.

Do not use when you have a fever.


Indemnification

This product is a dietary supplement, and should only be used as prescribed by a qualified acupuncturist, herbalist, phyto- or TCM therapist. This product is not intended to diagnose, treat, prevent or cure any disease. Always consult a qualified doctor or healthcare professional before using this. A healthy lifestyle is important, as is a varied, balanced diet, for which supplements are not a substitute.

TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. 1 packing adviced and then evaluate with your prescriber!

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