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This product is sold exclusively as a dietary supplement. It is not a medicine. Its use is based on traditional TCM applications.

Main benefits

  • Pattern Identification: Traditionally used for the TCM pattern of exuberant Heat and Fire toxin in the three burners, manifesting as high or persistent fever, irritability, insomnia, a bitter taste in the mouth, dark urine, and a tendency to inflammatory or suppurative conditions such as sores, red eyes, or nose/mouth ulcers in TCM description.

  • Core Function: The formula is classically said to drain Fire, clear Heat‑Toxin from the Heart, Liver, and Stomach, and cool the Blood.

  • Heat‑Toxin Relationship: Based on the TCM principle that exuberant Heat congeals Body Fluids into toxins and drives them into the Blood level, the formula strongly clears Heat from all three burners and resolves “Fire toxin,” thereby calming internal agitation and reducing inflammatory manifestations.

  • Key Ingredients: Huang Lian (Coptis) clears Heart and Stomach Fire; Huang Qin (Scutellaria) clears Heat from the upper burner and Lungs; Huang Bai (Phellodendron) drains Damp‑Heat from the lower burner; Zhi Zi (Gardenia) vents Heat from all three burners and promotes its elimination via the urine.

  • Emotional Component (TCM): Frequently used when internal Heat and Fire toxin are accompanied by restlessness, agitation, or a feeling of being “overheated” emotionally, reflecting the impact of Heart Fire and constrained Liver Heat on the Shen.

  • Region of Action: Primarily acts on the Heart, Liver, Stomach, and the Blood level within the three burners, with a focus on strong, short‑term Heat‑clearing rather than long‑term tonification.

  • Classical Heritage: First recorded in the Tang‑dynasty classic Wai Tai Mi Yao (Arcane Essentials from the Imperial Library), Huang Lian Jie Du Tang is regarded as the archetypal formula for “Heat‑Toxin blazing in the interior” and a benchmark for many later detoxifying prescriptions.


Zhenatura.com TCM: Herbal dietary supplements of Traditional Chinese Medicine origine according to European standards!

  • Strength 10:1
  • 120 tablets per bottle
  • Double or Triple the strength as regular brands
  • Less fillers and binders
  • No pharmaceuticals or dyes
  • Thorough lab testing (heavy metals, pesticides etc.)
  • Always made in controlled cGMP certified facility
  • Unbeatable value
  • European brand
TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. We advice always to use minimum 1 packing and then evaluate with your prescriber!
This product is a dietary (food) supplement, to be taken as directed by a qualified practitioner. It is not intended to treat, cure, diagnose or prevent any disease. Not to replace a varied diet. Not to be taken if nursing or if pregnant. Not to be consumed continuously for longer than 3 months.

Common uses

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Information for professionals

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Zhenatura Huang Lian Jie Du Tang Extra Strong is based on the classical Huang Lian Jie Du Tang ("Coptis Toxin-Resolving Decoction"), first recorded in the Tang‑dynasty medical text Wai Tai Mi Yao ("Arcane Essentials from the Imperial Library") by the physician Wang Tao. Within traditional Chinese herbal literature, this specific combination of four botanicals—Huang Lian (Coptis Rhizome), Huang Qin (Scutellaria Root), Huang Bai (Phellodendron Bark), and Zhi Zi (Gardenia Fruit)—was described as a method to "drain Fire from the Three Burners," "clear Heat," and "resolve toxicity" in accordance with the TCM theoretical framework. These descriptions belong exclusively to the traditional conceptual system of Chinese medicine and do not refer to modern anatomy, psychology, or scientifically validated physiological effects.

1
Type 2 Diabetes and Vascular Protection
https://pmc.ncbi.nlm.nih.gov/articles/PMC3955108/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • A 2012 clinical trial in T2DM patients found that early and long‑term HLJDT therapy exerted anti‑inflammatory and antioxidant effects and protected vascular endothelium, potentially reducing cardiovascular complications.

  • In diabetic rats, HLJDT significantly reduced fasting blood glucose, fasting insulin, total cholesterol, triglycerides, angiotensin II, and von Willebrand factor, and increased HDL and nitric oxide levels.

  • Authors concluded that HLJDT may improve metabolic control and protect vascular endothelium in T2DM through anti‑inflammatory and antioxidant mechanisms.


2
Sepsis and Systemic Inflammation
https://pmc.ncbi.nlm.nih.gov/articles/PMC3865632/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • In a cecal ligation and puncture (CLP) rat model of sepsis, prophylactic HLJDT:

    • Improved survival and markedly reduced liver and lung injury (less inflammatory infiltrate, congestion, necrosis).

    • Lowered plasma ALT/AST, indicating hepatoprotection.

    • Suppressed pro‑inflammatory cytokines (TNF‑α, IL‑1, IL‑6, IL‑17A).

    • Enhanced bacterial clearance by increasing phagocytic activity of peritoneal macrophages.

    • Reversed CLP‑induced Th1→Th2 shift by restoring IFN‑γ and reducing IL‑4, re‑balancing Th1/Th2 toward Th1 predominance.

  • These results show HLJDT can limit overwhelming inflammation, improve immune balance, and protect organs in experimental sepsis.


3
Atopic Dermatitis and Skin Inflammation
https://pubmed.ncbi.nlm.nih.gov/31075381/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • A 2019 study in a DNCB‑induced mouse model of atopic dermatitis (AD) showed that HLJDT:

    • Significantly improved AD‑like lesion scores, reduced ear and skin edema and inflammatory infiltration.

    • Down‑regulated serum IL‑1α, IL‑1β, IL‑2, IL‑4, IL‑5, IL‑6, IFN‑γ and other Th1/Th2 cytokines.

    • Suppressed phosphorylation of MAPKs (ERK, JNK, p38) and NF‑κB, indicating inhibition of the MAPKs/NF‑κB pathway.

  • Authors concluded HLJDT may be a potential treatment for AD via broad anti‑inflammatory signaling inhibition.

  • Clinical TCM sources likewise recommend HLJDT for acute flares of atopic dermatitis with marked redness, swelling, heat and oozing, emphasizing its “heat‑toxin clearing” function.


4
Neuroprotection, Stroke, and Gut–Brain Axishttps
https://pubmed.ncbi.nlm.nih.gov/41197341/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • A 2025 Phytomedicine study reported that HLJDD alleviates diabetic ischemic stroke (DIS) by modulating the gut–brain axis via microbiota‑derived short‑chain fatty acids (SCFAs).

    • HLJDD improved neurological outcomes, reduced infarct volume, and normalized microglial activation in DIS models.

    • It restored SCFA‑producing bacteria and increased circulating SCFAs, linking microbiota changes to neuroprotection.

  • HLJDD has also shown neuroprotective and anti‑inflammatory actions in general neurological models and is used clinically for “excess Heat” patterns associated with agitation, insomnia, and delirium.


5
Antiviral and Antitumor Activity
https://www.nature.com/articles/s41598-017-15733-7

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • A 2017 Scientific Reports study found HLJDT inhibits H1N1 neuraminidase (NA‑1) activity; plasma pharmacokinetic profiling identified multiple absorbed constituents with neuraminidase inhibitory activity.

  • In human hepatocellular carcinoma cell lines (HepG2, PLC/PRF/5), HLJDT inhibited tumor cell growth, reduced tumor volume, and improved survival in experimental models, attributed to anti‑inflammatory and pro‑apoptotic actions.


6
Rheumatoid Arthritis and Inflammatory Disease (network pharmacology)
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.740266/full

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

  • Network pharmacology and molecular docking analysis of HLJDD in rheumatoid arthritis (RA) identified multiple active compounds (e.g., berberine, baicalin, geniposide) and core targets: TNF, IL‑6, IL‑1β, MAPKs, NF‑κB.

  • Enriched pathways include TNF signaling, NF‑κB, Th17 differentiation, and HIF‑1 signaling, consistent with HLJDD’s broad anti‑inflammatory effect across diseases.

For Huang Lian Jie Du Tang, take 3 tablets 2 times per day. These should be taken before or after meal.

Total pieces in package: 120 tablets

Dosage: 3 tablets

Frequency: 2 times a day before or after meal

Do not exceed the recommended daily dose. This supplement is not a substitute for a balanced diet.


Side effects

Cold Sensation

Fatigue

Gastrointestinal discomfort


Allergies

Individuals allergic to any of the herbal ingredients should avoid use. Discontinue immediately if any allergic reactions, such as rash, itching, or swelling, occur.

No known allergies.


Avoid medicine interactions

Anticoagulants

Anticoagulants or Antiplatelet Drugs

Antiplatelet medications

Chemotherapy Agents

Chemotherapy or Immunosuppressive Drugs

Medications Metabolized by CYP3A4, CYP2C9, and P-Glycoprotein


Precautions

Do not use if pregnant or breastfeeding.

Consult your doctor if taking medicines or under medical care.

Not suitable for people with high blood pressure.

Stop use at least two weeks before surgery.


Indemnification

This product is a dietary supplement, and should only be used as prescribed by a qualified acupuncturist, herbalist, phyto- or TCM therapist. This product is not intended to diagnose, treat, prevent or cure any disease. Always consult a qualified doctor or healthcare professional before using this. A healthy lifestyle is important, as is a varied, balanced diet, for which supplements are not a substitute.

TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. 1 packing adviced and then evaluate with your prescriber!

Avoid medicine interactions

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SKU: ZHEN0127

GTIN: 8721472361216