Main benefits
  • Pattern identification: Traditionally used for the TCM pattern of Blood stasis obstructing the head and sensory orifices, where circulation in the channels of the head, face, and upper body is impaired by congealed Blood.​

  • Name and core idea: [translate:通窍活血汤] means “Unblock the Orifices and Invigorate the Blood Decoction.” Its core function is to invigorate Blood, dispel stasis, and open the orifices of the head (nose, ears, eyes) according to classical theory.​

  • Key ingredients and actions: Tao Ren (Persica Kernel) and Hong Hua (Safflower) strongly invigorate Blood and break stasis in the channels of the upper body. Chi Shao (Red Peony) cools and moves Blood, helping to disperse congealed stasis. Chuan Xiong moves both Qi and Blood and guides the formula’s action to the head and face. Sheng Jiang (Fresh Ginger), Cong Bai (Scallion White), and Da Zao (Jujube) warm and regulate the channels and harmonize the Ying and Wei in the upper body.​

  • Head and orifice focus: Classically indicated for “accumulation of Blood stasis in the head and face,” with symptoms described in TCM terms such as chronic headache, vertigo, tinnitus, dark or purplish facial complexion, or darkness around the eyes, all interpreted as manifestations of stasis obstructing the orifices.​

  • Upper‑body Blood‑stasis formula: Within Wang Qing‑ren’s “Blood stasis” system, Tong Qiao Huo Xue Tang is the representative formula when the primary location of stasis is the head and sensory orifices, as opposed to chest (Xue Fu Zhu Yu Tang) or abdomen (Ge Xia/Shao Fu Zhu Yu Tang).​

  • Modern research perspective (TCM context): Contemporary pharmacological studies investigate the formula’s effect on cerebral circulation and Blood‑Brain Barrier function, describing it as a “blood‑activating, orifice‑opening” prescription for head‑level stasis patterns in TCM.​

  • Classical heritage: Attributed to Wang Qing‑ren in Yi Lin Gai Cuo (Correcting the Errors Among Physicians, 1830), it is now a standard “blood‑invigorating, orifice‑opening” formula listed under the Invigorate the Blood and Dispel Stasis category in many modern TCM formularies.​


Zhenatura.com TCM: Herbal dietary supplements of Traditional Chinese Medicine origine according to European standards!

  • Strength 10:1
  • 120 tablets per bottle
  • Double or Triple the strength as regular brands
  • Less fillers and binders
  • No pharmaceuticals or dyes
  • Thorough lab testing (heavy metals, pesticides etc.)
  • Always made in controlled cGMP certified facility
  • Unbeatable value
  • European brand
TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. We advice always to use minimum 1 packing and then evaluate with your prescriber!
This product is a dietary (food) supplement, to be taken as directed by a qualified practitioner. It is not intended to treat, cure, diagnose or prevent any disease. Not to replace a varied diet. Not to be taken if nursing or if pregnant. Not to be consumed continuously for longer than 3 months.

Common uses

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Information for professionals

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Zhenatura Tong Qiao Huo Xue Tang Extra Strong is based on the classical Tong Qiao Huo Xue Tang, first recorded in the Qing‑dynasty medical text Yi Lin Gai Cuo by Wang Qing‑Ren. In traditional Chinese herbal literature, this specific combination of botanicals (including Red Peony, Peach Kernel, and Ligusticum) was described as a method to "invigorate the Blood" and "open the orifices" within the TCM theoretical framework. These descriptions refer exclusively to the traditional conceptualization of the ingredients in TCM and do not relate to modern anatomical structures, brain function, or scientifically verified physiological effects.

1
Ischemic Stroke
https://pubmed.ncbi.nlm.nih.gov/34600074/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Meta-Analysis of RCTs:

A 2022 systematic review included 17 randomized controlled trials (RCTs) with 1,489 patients, finding that TQHXD significantly improved clinical effective rate, neurological deficit scores, activities of daily living (ADL), and hemorheology (hematocrit, fibrinogen, plasma viscosity, platelet adherence) in acute ischemic stroke.
Conclusion: TQHXD is effective for acute ischemic stroke, but higher-quality, large-sample trials are needed for definitive evidence.


2
Combination with Western Medicine
https://pmc.ncbi.nlm.nih.gov/articles/PMC7758136/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

A 2020 meta-analysis of 40 RCTs (3,260 patients) found that TQHXD combined with standard Western medicine significantly reduced NIHSS (neurological deficit) scores, serum hs-CRP, plasma viscosity, fibrinogen, cholesterol, and triglycerides, and improved ADL (Barthel index) and overall treatment efficiency.

Safety: No significant increase in adverse events was observed.


3
Vascular Dementia (VD)
https://www.heraldopenaccess.us/openaccess/application-of-tongqiao-huoxue-decoction-in-the-treatment-of-cerebrovascular-disease-a-review

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Mechanistic and Animal Studies:

  • TQHXD improved learning and memory in rat models of VD, enhanced hippocampal neuron morphology, increased dendritic length and spine density, and promoted synaptic remodeling.

  • The neuroprotective effect is likely mediated through activation of the cAMP/PKA/CREB signaling pathway, reducing apoptosis and oxidative stress.

Clinical Evidence: Clinical studies report that TQHXD improves cognitive scores (MoCA), daily living ability (ADL), and reduces neuroinflammation in VD patients.


4
Blood-Brain Barrier and Neuroprotection
https://pubmed.ncbi.nlm.nih.gov/29093286/

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Preclinical Study:

TQHXD protected hippocampal neurons and maintained blood-brain barrier (BBB) integrity in cerebral ischemia models by upregulating tight junction proteins (ZO-1, occludin, claudin-5) and downregulating aquaporin-4 and MMP-9.

Active compounds such as muscone, ligustilide, and hydroxysafflor yellow A were detected in cerebrospinal fluid, supporting their role in BBB protection.


5
Broader Cerebrovascular and Neurological Indications
https://www.heraldopenaccess.us/openaccess/application-of-tongqiao-huoxue-decoction-in-the-treatment-of-cerebrovascular-disease-a-review

Please note: This summary is a concise interpretation of the original article; please refer to the source for the full context and details.

Clinical Reviews:

  • TQHXD is used for a wide range of head and face disorders, including ischemic and hemorrhagic stroke, vertebrobasilar artery dilation, vascular dementia, and posterior circulation ischemic vertigo.

  • It is associated with improvements in cognitive function, daily living, and reduction of depression scores in post-stroke depression.


For Tong Qiao Huo Xue Tang, take 3 tablets 2 times per day. These should be taken before or after meal.

Total pieces in package: 120 tablets

Dosage: 3 tablets

Frequency: 2 times a day before or after meal


Side effects

Flushing skin

Mild Digestive discomfort

Mild dizziness

Mild Menstrual Spotting

Restlessness


Allergies

Individuals allergic to any of the herbal ingredients should avoid use. Discontinue immediately if any allergic reactions, such as rash, itching, or swelling, occur.

Apiaceae Family

Peach Kernel

Red Peony Root

Safflower Allergy


Avoid medicine interactions

Anticoagulants or Antiplatelet Drugs

Hormonal medications

NSAIDs (Ibuprofen, Aspirin, Naproxen)

Sedatives or CNS-Acting Drugs


Precautions

Discontinue use if allergic reaction occurs.

Consult your herbalist or physician before use if you are taking other medications or receiving other medical treatments.

Consult your herbalist or doctor before use if you have high blood pressure, or if you are children, old or very weak.

Keep out of reach of children.


Indemnification

This product is a dietary supplement, and should only be used as prescribed by a qualified acupuncturist, herbalist, phyto- or TCM therapist. This product is not intended to diagnose, treat, prevent or cure any disease. Always consult a qualified doctor or healthcare professional before using this. A healthy lifestyle is important, as is a varied, balanced diet, for which supplements are not a substitute.

TCM traditional Chinese Patents do not work immediate, it takes some time before you (and your organs) will experiences the benefits. 1 packing adviced and then evaluate with your prescriber!

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